Ethically-sourced, Difficult-to-Find Human Tissue Samples

Simple, streamlined human tissue sample procurement—it’s possible with iSpecimen. Whether you need fully consented FFPE blocks with specific variant profiles, archived samples, or prospectively-collected diseased tissue over time with matched quad sets, we’ll handle the procurement gymnastics to get your biospecimens delivered.

Because we have access to the full electronic medical record, we can select and annotate specimens with molecular and genetic characterizations, treatment data, outcomes data, and other pertinent patient and specimen data.

Let us know the specific tissue samples you need and we’ll tap into our global network of biospecimen providers.

histopathology cassette with organ embedded paraffin
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Fresh Tissue

Obtain fresh solid tissue from patients with medical conditions including all types of cancers and benign conditions. Our revolutionary online Marketplace connects researchers to a range of remnant human tissue samples.

  • Prospectively collect samples with specific genomic profiles
  • Get samples collected under non-standard protocols
  • Receive longitudinal or follow-up data associated with your biospecimens
  • Get samples matching disease stage, histology, and laboratory test results
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FFPE Tissue

Access an extensive global network of FFPE human tissue from clinical remnant, banked, or prospective collections. We help to source samples that reflect the patient diversity that today’s medical research requires.

  • Deep datasets including pathology reports, collection year/country, and consent status
  • Samples from diseased and healthy normal donors
  • Custom collections, just say the word!
  • Archived, waiver-of-consent blocks for reliable, cost-effective option
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Matched Sets

Compare abnormal biology against the normal with matched tissue and biofluid sets, as well as longitudinal collections from the same patient. Our matched sets can go beyond pairs to include quad sets making your comparisons more meaningful.

Choose a combination of:

  • Frozen fresh human tissue for histology
  • Archived formalin-fixed paraffin-embedded (FFPE) blocks for staining and IHC
  • Human whole blood for DNA analysis
  • Peripheral blood mononuclear cells (PBMCs) for cultivating cell lines
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Frozen Tissue

Having a reliable alternative to sourcing fresh tissue, one that closely mimics receiving fresh surgical tissue, but with added flexibility and immediate availability, can help keep your research projects on track. iSpecimen has access to a large inventory of snap frozen tissue for genomic tissue research as well as viably cryopreserved tissue (available within a two week lead time).

  • Get frozen cancerous tissue with adjacent tissue and matched biofluids
  • Suitable replacement for fresh tissue upon thaw; versatile range of applications
  • Viably frozen retains tissue heterogeneity (contains cancer stem cells and TILs).
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Tissue Microarrays (TMA)

Access a global repository of Tissue Microarray samples from diseased and healthy patients. iSpecimen’s extensive global network provides access to high quality TMAs from hundreds of providers and repositories around the world, providing sample and patient diversity that precision medicine requires.

  • Increase throughput of sample analysis
  • Conserve precious tissue resources
  • Reduce reagent consumption
Research-Biospecimen

Finding the Right Human Tissue for Your Research

The iSpecimen Marketplace® changes the paradigm, offering single-source access to millions of human tissue samples and patients across a diverse network of providers—quickly and compliantly

Disease Indications

Wide-ranging, highly specific

If you need it, chances are, we can get it. Our large and growing network of partners connect their electronic medical record data directly to the iSpecimen Marketplace, allowing us to source biospecimens for research with highly specific characteristics for a broad range of disease indications. Below are some examples.

  • Allergic Rhinitis
  • Allergies (Seasonal)
  • Ankylosing Spondylosis
  • Asthma
  • Autoimmune Hepatitis
  • Autoimmune Liver Disease
  • Goodpastures
  • Graves’ Disease
  • Hashimoto’s Thyroiditis
  • Plaque Psoriasis
  • Rheumatoid Arthritis (RA)
  • Scleroderma
  • Sjogrens Syndrome
  • Systemic Lupus Erythematosus (SLE)
  • Systemic Sclerosis
  • Thrombocytopenia
  • ADD
  • ADHD
  • Alzheimer’s Disease
  • Dementia
  • Epilepsy and Seizures
  • Major Depressive Disorder
  • Multiple Sclerosis
  • Parkinson’s Disease
  • Postpartum Depression
  • Chagas
  • Chlamydia
  • COVID-19 (SARS-CoV-2)
  • Ebstein Barr Syndrome (EBV/Mononucleosis)
  • Gonorrhea
  • Hepatitis A
  • Hepatitis B
  • Hepatitis C
  • Herpes
  • HIV / AIDS
  • HTLV
  • Influenza
  • Invasive fungal infections
  • Lyme Disease
  • Syphilis
  • Toxoplasmosis
  • Zeka
  • Abnormal Menstrual Cycle
  • Cervical cancer
  • Cysts
  • Endometriosis
  • Menopause
  • Ovarian cancer
  • Ovarian Disease
  • Polycystic ovarian syndrome
  • Polyps
  • Preeclampsia
  • Pregnancy
  • Reproductive health
  • Uterine Fibroids

Solid tumors

  • Bladder Cancer
  • Brain / Glioblastoma
  • Breast Cancer
  • Colorectal / Rectal Cancer
  • Esophageal Cancer
  • Head / Neck Cancer
  • Kidney Cancer
  • Liver Cancer
  • Lung Cancer
  • Melanoma
  • Non-Small Cell Lung Cancer NSCLC
  • Ovarian Cancer
  • Pancreatic Cancer
  • Prostate Cancer
  • Small Cell Lung Cancer SCLC
  • Uterine Cancer

Hematologic malignancies

  • Acute Myeloid Leukemia AML
  • B-cell Lymphoma
  • Chronic Lymphocytic Leukemia CLL
  • Leukemia
  • Lymphoma
  • Mixed lineage leukemia MLL
  • Multiple Myeloma
  • Myelodysplastic Syndrome MDS
  • Non-Hodgkin’s Lymphoma
  • Swabs, serum, plasma, blood and urine from individuals testing positive for COVID-19 and recovering patients
  • COVID-19 co-morbidities
  • Biospecimens of COVID-19 (SARS-CoV-2) variants
  • Alagille syndrome
  • Alcoholic hepatitis
  • Alpha-1 Antitrypsin deficiency
  • Bile duct cancer
  • Biliary atresia
  • Cirrhosis
  • Hemochromatosis
  • Hepatitis C
  • Hepatitis B
  • Liver transplant remnants
  • NAFLD
  • Angina
  • Atherosclerosis
  • Atherosclerotic Cardiovascular Disease (ASCVD)
  • Atherosclerotic Heart Disease
  • Atrial Fibrillation/Flutter (A-fib)
  • Cardiomegaly
  • Cardiomyopathy
  • Cardiovascular Disease
  • Carotid Artery Disease
  • Carotid Disease
  • Congestive Heart Failure (CHF)
  • Coronary Artery Disease
  • Deep Vein Thrombosis (DVT)
  • Dilated Cardiomyopathy
  • Heart Failure
  • Hemophilia
  • Hypertension
  • Hypolipidemia
  • Idiopathic Dilated Cardiomyopathy
  • Ischemia/Infarction
  • Ischemic Cardiomyopathy
  • Ischemic Heart Disease
  • Non-ischemic Cardiomyopathy
  • Vascular tissue from aortic surgery
  • Celiac Disease
  • Colorectal Disease
  • Crohn’s Disease
  • Crohn’s Disease
  • Inflammatory Bowel Disease (IBD)
  • Irritable-Bowel Syndrome (IBS)
  • Polyps
  • Pre-colonoscopy healthy controls
  • Ulcerative Colitis (UC)
  • Asthma
  • Chronic Bronchitis
  • Chronic Sinusitis
  • COPD (Chronic Obstructive Pulmonary Disease)
  • Cystic Fibrosis (CF)
  • Influenza
  • Lung Cancer
  • Pulmonary Edema

Recent Human Tissue Sample Procurement Successes

Triple Negative Breast Cancer FFPE Blocks

By streamlining procurement logistics we were able to deliver the required FFPE blocks to the client within a week — supporting their therapeutic discovery pursuits.

Prospectively Collected Fresh Ovarian Cancer Tumors with Specific Mutations

A precision medicine company needed ovarian cancer tumor tissue samples with specific TP53 and KRAS mutations along with a wealth of data for each sample. We were able to collect these samples (at least 200 mg) by connecting with numerous providers in our network.

Frozen Checkpoint Inhibitor Sets

Biotech company rapidly procured frozen cancerous tissue, corresponding normal adjacent tissue, and matched sets of plasma and peripheral blood mononuclear cells from patients treated with checkpoint inhibitors.

“This process previously required a lot of paperwork and time. iSpecimen makes it so much easier and quicker.”

LeeAnn Talarico

Associate Director, Takeda Oncology

Custom and Prospective Collection Experts

When you require a custom collection, iSpecimen experts are here to help. We help to ensure that sample matching aligns tightly with your study requirements while also closely managing your projects, from inquiry to fulfillment.