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Hematopoietic stem and immune cells

The iSpecimen Marketplace offers hematologic tissue products containing hematopoietic stem and immune cells prospectively collected from healthy U.S donors according to US CFR requirements.  Choose among Whole Bone Marrow Aspirate, Mononuclear Cell (MNCs) Leukapheresis (non-mobilized leukopacks), Mobilized Mononuclear Cell (MMNCs) Leukapheresis (mobilized leukopacks) and Peripheral Whole Blood products.

Hematopoietic stem and immune cells

Hematologic products available through the iSpecimen Marketplace have an important source of the following primary cell types:

  • Hematopoietic stem cells (HSCs or CD34+): oligopotent stem cells that give rise to each mature blood cell type
  • Mesenchymal stem cells (MSCs): in unprocessed whole bone marrow aspirate (bone marrow stromal stem cells), multipotent stem cells capable of differentiating into osteoblasts, myocytes, adipocytes, chondrocytes; MSCs also possess immunomodulatory function
  • Immune cells: Pan T (CD3+), Helper T (CD4+), Cytotoxic T (CD8+), NK (CD 56+), B cells (CD 19+), Monocytes (CD14+), antigen presenting cells (dendritic), neutrophils, macrophages, and related cell types.

Available Fresh Products

Each Donor is assessed for medication, lifestyle, and medical history,  tested for HBV, HCV, HIV and serological tests as a minimum, with an option to test for an expanded panel of infectious diseases.

These cell products contain primary cells utilized in autoimmune and infectious disease research, drug discovery and preclinical development, research and development of stem cell and immunotherapies, diagnostic assays involving cell-based calibrators and controls, and numerous other life science research applications.

PRODUCT DESCRIPTION
Whole Bone Marrow Aspirate Healthy donors
Up to 100 ml pack sizes (Researchers may also request up to 100 ml of autologous blood)
Normal Mononuclear Cells (MNCs) Collection – Leukapheresis Non-Mobilized leukopacks
Healthy donors
Full leukopacks, >300 ml
G-CSF Mobilized Mononuclear Cells (MMNCs) Collection –     Leukapheresis Mobilized leukopacks
Day 1, Day 2, Day 3, Day 4, Day 5 (second day collection available)
Healthy donors
Full leukopacks, >300 ml
Pheripheral Whole Blood Healthy donors
Up to 500 ml
(various collection tube types available)
Diseased Whole Blood, Plasma, Serum, PBMC, and Bone Marrow Mononuclear Cells (BMMCs) Diseased donors
Varied disease states (e.g. oncology,  hematology, autoimmune, and others)
Pack size options available
Clinical reports

How the ispecimen marketplace helps you

  • Our growing partner network on the iSpecimen Marketplace offers increased access to numerous Donor Centers and clinical collection sites covering both healthy and diseased hematologic tissue.
  • Search cell product types, refine by selecting donor attributes, specify exclusion criteria and data annotation requirements, and submit a quote request – all from the iSpecimen Marketplace.
  • Obtain the best possible cell phenotype(s) for your specific research application by accessing a larger eligible donor pool with diverse phenotypes and broad selection of customizable donor attributes.

Recent hEMATOPOIETIC Cells Projects and Collections

Here are some recent examples of hematopoietic and immune cell products  provided to researchers.

  • Fresh whole leukopaks from adult non-smoker, delivered overnight to the east coast
  • Frozen PBMCs from 10 donors with hepatocellular carcinoma plus 10 matched health controls (age, sex, and race)
  • Frozen BMMCs from 40 patients with active cases of AML, 1M-10M cells per vial